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The movie that had the highest box office profit that was adapted from a T.V. cartoon is Scooby-Doo, with a lifetime gross of $153,294,164.

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In the realm of cinematic adaptations, few films have managed to capture the essence of their source material while achieving significant commercial success. One such standout is "Scooby-Doo," the live-action adaptation of the beloved animated television series. Released in 2002, this film not only brought the iconic Mystery Inc. gang to life but also achieved remarkable box office success, grossing an impressive $153,294,164 worldwide. This achievement makes it the most profitable movie adapted from a TV cartoon, a testament to its enduring appeal and the clever execution of its creators.

The original "Scooby-Doo, Where Are You!" cartoon series, which debuted in 1969, quickly became a staple of Saturday morning television. Its blend of mystery, humor, and supernatural elements, coupled with the lovable Great Dane, Scooby-Doo, and his human companions, captured the imaginations of audiences young and old. Translating this animated charm into a live-action format was no small feat, yet the 2002 film managed to do so with flair. Directed by Raja Gosnell and featuring a star-studded cast including Freddie Prinze Jr., Sarah Michelle Gellar, Matthew Lillard, and Linda Cardellini, the movie successfully brought the quirky characters and their spooky adventures to a new generation.

One of the key factors behind the film's success was its ability to balance nostalgia with modern sensibilities. The screenplay, penned by James Gunn, cleverly incorporated elements familiar to fans of the original series while introducing fresh humor and a contemporary twist. The film's plot revolves around the gang reuniting to solve a mystery on Spooky Island, a popular theme park plagued by supernatural occurrences. This setting allowed for a visually engaging experience, with vibrant sets and special effects that enhanced the film's appeal.

Moreover, the casting choices played a significant role in the movie's success. Matthew Lillard's portrayal of Shaggy was particularly praised for its uncanny resemblance to the animated character, both in voice and mannerisms. The chemistry among the cast members brought the camaraderie of Mystery Inc. to life, making it easy for audiences to connect with the characters they had grown to love on television.

"Scooby-Doo" also benefited from a marketing strategy that capitalized on the franchise's established fan base while reaching out to new viewers. The film's promotional campaign included tie-ins with fast-food chains, merchandise, and a soundtrack featuring popular artists of the time, all of which contributed to its widespread appeal.

In conclusion, the 2002 "Scooby-Doo" film stands as a shining example of how to successfully adapt a beloved TV cartoon into a live-action movie. Its impressive box office performance is a testament to the enduring popularity of Scooby-Doo and his gang, as well as the filmmakers' ability to capture the spirit of the original series while appealing to contemporary audiences. As the most profitable movie adapted from a TV cartoon, "Scooby-Doo" continues to hold a special place in the hearts of fans, proving that the mystery-solving adventures of Mystery Inc. are as timeless as ever.