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The opposite of deja vu is "jamais vu", when something you know to be familiar feels unreal or novel in some way.

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Jamais vu, a French term that translates to "never seen," is a psychological phenomenon where a person does not recognize a situation, person, or place that is actually familiar. This intriguing experience is essentially the opposite of déjà vu, which involves a feeling of having already experienced something that is actually happening for the first time. While déjà vu has become a well-known concept, often depicted in literature and films, jamais vu is less commonly discussed but equally fascinating due to its mysterious nature.

Jamais vu occurs when there is a temporary anomaly in the recognition process of the brain. This can cause a sudden and sometimes disturbing sensation that something very familiar is strangely unfamiliar. For example, a common word can suddenly appear foreign or one's daily commute might inexplicably feel like a new route. The feeling is generally fleeting, leaving as abruptly as it arrives, but it can significantly jar a person’s sense of reality during the moment of dissociation.

The causes behind jamais vu are not fully understood, but it is studied within the fields of psychology and neurology. It can be associated with fatigue, stress, or certain neurological conditions. It is also observed as a symptom in some cases of epilepsy and in other neuropsychological conditions. Sometimes, excessive repetition triggers jamais vu; when a person repeats a word so many times it loses its meaning and familiarity, they experience what is referred to as semantic satiation, which can produce a sensation resembling jamais vu.

Despite its lesser recognition compared to déjà vu, jamais vu raises important questions about perception and memory. It challenges our understanding of how memory functions and how the brain processes the everyday normality of the world around us. The phenomenon serves as a reminder of the complexity of the human brain and its sometimes inexplicable behavior. By studying occurrences like jamais vu, researchers continue to uncover the vast mysteries of cognitive function, offering broader insights into conditions that affect human perception and memory.